Endocrine Abstracts

The hormone oestrogen is reported to be the most widely prescribed drug worldwide through its use in the contraceptive pill and in hormone replacement therapy (HRT). Oestrogen and HRT has been widely prescribed for prevention of osteoporosis and relief of menopausal symptoms. However, as women age, their risk of stroke and heart disease also increases, particularly after the menopause. The effects of oestrogen on stroke risk and on the ischaemic brain are complex and still not...

Background: By providing a non-invasive, functional insight into brain chemistry, MRS has the potential to provide objective longitudinal data on mammalian brain development.Aims: To assess the sexual dimorphism in rodent brain chemistry and development using in vivo MRS.Methods: 26 (19 males) Sprague–Dawley rats were scanned at 6 weeks and 12 male rats at 10 weeks using a 7T MRI scanner. Testosterone concentrations w...